Potential therapeutic effects of dipyridamole in the severely ill patients with COVID-19

(Compuscript Ltd) Effective antivirals with safe clinical profile are urgently needed to improve the overall COVID-19 prognosis. In an analysis of a randomly collected cohort of 124 patients with COVID-19, the authors found that hypercoagulability as indicated by elevated concentrations of D-dimers was associated with disease severity. By virtual screening of a U.S. FDA approved drug library, the authors identified an anticoagulation agent dipyridamole (DIP) in silico, which suppressed SARS-CoV-...