Promising phase 1 trial results: Use of sotorasib (AMG 510) in patients with solid tumors

(City of Hope) A phase 1 clinical trial of sotorasib (AMG 510) in patients with heavily pretreated advanced solid tumors shows encouraging anti-cancer activity, especially in lung and colorectal cancers, reports a new study led by City of Hope and other renowned comprehensive cancer centers. 'KRAS mutations have been linked with worse treatment outcomes in a variety of cancers,' Dr. Marwan Fakih said. 'This study has, in some cases, demonstrated a median progression-free survival that is two tim...