Lipids, lysosomes, and autophagy: The keys to preventing kidney injury

(Osaka University) Lysosomes are cellular waste disposal organelles containing potent enzymes that cause cellular damage if they leak out of ruptured lysosomes. In a recent study led by Osaka University, researchers found that several distinct pathways involved in the repair or elimination of damaged lysosomes work together in response to lysosomal damage. The proper activation and function of these pathways was essential for preventing kidney injury in a mouse model of oxalate crystal-induced k...