The making of memory B cells and long-term immune responses

(Osaka University) Researchers at Osaka University in Japan have identified two factors necessary for the production of memory B cells, the cells of the immune system that allow fast responses to re-infection. Without expression of the protein Bach2 and reduced mTORC1 signaling, B cells cannot become memory B cells, and are instead recycled. These findings could be useful for creating efficient vaccines that remain effective decades after initial infection.