How allergens trigger itching: Finding points to new targets for allergy drug development

(Massachusetts General Hospital) A key step in the immune system's response to allergens has been uncovered by researchers at Massachusetts General Hospital. They have shown that a neuropeptide called Substance P is released by certain neurons in the skin when they detect allergens, and that this substance is essential in the development of allergen-induced immune responses. This research could lead to the development of new and better methods to treat and prevent allergies.