Unraveling the genetic determinants of small vessel vasculitis

(University of Tsukuba) Researchers from the University of Tsukuba have shown that the single-nucleotide variants of TERT and DSP, which promote risk for idiopathic pulmonary fibrosis (IPF), are significantly associated with susceptibility to microscopic polyangiitis and myeloperoxidase-ANCA associated vasculitis. Interestingly, there was no clear link to the severe complication interstitial lung disease (ILD). These findings suggest a shared genetic susceptibility between IPF and ANCA-associate...