Multisystem failure regarding frailty necessitates multisystem intervention

(Johns Hopkins Medicine) Physicians understand frailty as a dysregulation among multiple systems in the body that make it less resilient and unable to recover completely when faced with a physical challenge such as injury or illness. "Defining frailty on a scientific level, however, has been a challenging task," explains Ravi Varadhan, Ph.D., associate professor of oncology in the Division of Biostatistics and Bioinformatics at the Johns Hopkins Kimmel Cancer Center.