Targeting drug-resistant breast cancer with estrogen

(Dartmouth-Hitchcock Medical Center) Researchers at Dartmouth's and Dartmouth-Hitchcock's Norris Cotton Cancer Center show better long-term control of drug-resistant breast cancer growth in mice by switching between estrogen and anti-estrogen therapies. An ongoing clinical trial will determine whether this cycling strategy is effective in human patients with advanced breast cancer. By studying molecular characteristics of cancer cells that respond to estrogen therapy, the team hopes to determine...