Nrf2: The custodian regulating oxidative stress and immunity against acrylamide toxicity

(Tokyo University of Science) Acrylamide, which is extensively used in industries, causes peripheral neuropathy or encephalopathy. Now, scientists from Japan examined the response against oxidative stress in acrylamide-induced neurotoxicity and found that nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulator of the immune system and response to oxidative stress, was at the center of this toxicity. They found that Nrf2 plays a protective role by increasing the expression of prote...