Computational mid-infrared photothermal imaging unveils intracellular tau aggregates

As a prominent form of amyloid protein, tau aggregates have emerged as a primary focus of research for uncovering the mechanisms underlying neurodegeneration. Various types of tau aggregates, including tau fibrils and oligomers, have been implicated in a wide range of neurodegenerative diseases. However, the formation mechanism of tau aggregates and the associated disease pathways remain poorly understood.