People with obsessive-compulsive spectrum disorders (OCSDs), chronic tic disorders (CTDs), and ADHD often suffer from significant sleep disturbances, and a new review suggests that disruptions in the cortico-striatal-thalamo-cortical (CSTC) pathway may be the reason why. The review highlights how dopamine and GABA dysregulation in CSTC circuitry contributes to both poor sleep and the disorders themselves, suggesting a bidirectional and additive relationship.
People with obsessive-compulsive spectrum disorders (OCSDs), chronic tic disorders (CTDs), and ADHD often suffer from significant sleep disturbances, and a new review suggests that disruptions in the cortico-striatal-thalamo-cortical (CSTC) pathway may be the reason why. The review highlights how dopamine and GABA dysregulation in CSTC circuitry contributes to both poor sleep and the disorders themselves, suggesting a bidirectional and additive relationship.
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