A groundbreaking study reveals that reshaping nuclear speckles - tiny structures inside cell nuclei that regulate protein maintenance - could be a novel way to treat proteinopathies like Alzheimers, Parkinsons, and prion diseases. Researchers found that pyrvinium pamoate, an existing FDA-approved drug, alters the surface tension of nuclear speckles, making them less round and more effective at supporting proteostasis.
A groundbreaking study reveals that reshaping nuclear speckles - tiny structures inside cell nuclei that regulate protein maintenance - could be a novel way to treat proteinopathies like Alzheimers, Parkinsons, and prion diseases. Researchers found that pyrvinium pamoate, an existing FDA-approved drug, alters the surface tension of nuclear speckles, making them less round and more effective at supporting proteostasis.
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