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Psilocybin Rewire Brain Circuits Tied to Pain and Mood

Neuroscience News - 2 Oct 2025 19:46
Psilocybin Rewire Brain Circuits Tied to Pain and Mood New research shows that psilocybin, the active compound in psychedelic mushrooms, can reduce both chronic pain and pain-related depression by modulating brain circuits rather than acting at the site of injury. In mouse studies, a single dose provided pain relief and mood benefits lasting nearly two weeks by targeting the anterior cingulate cortex.
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