The native brain protein Arc mediates the intercellular transmission of toxic Tau via extracellular vesicles in Alzheimer's disease. While Arc helps sick neurons survive longer by expelling toxic Tau aggregates, it simultaneously promotes the spread of pathology to healthy cells, identifying the extracellular space as a prime "mid-flight" therapeutic target.
The native brain protein Arc mediates the intercellular transmission of toxic Tau via extracellular vesicles in Alzheimer's disease. While Arc helps sick neurons survive longer by expelling toxic Tau aggregates, it simultaneously promotes the spread of pathology to healthy cells, identifying the extracellular space as a prime "mid-flight" therapeutic target.
Share this Article
Recommended